Gold Member Since 2017
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Guangzhou Longfine Biotechnology Co., Ltd.

Dutasteride Powder, Dutasteride Manufacturer, Dutasteride manufacturer / supplier in China, offering Top Quality Dutasteride Powder (164653-23-9), Steroids Factory Supply Pure Epiandrosterone Powder, Ziprasidone Intermediate/5-Chloroethyl-6-Chloro-1, 3-Dihydro-2h-Indole-2-One (118289-55-7) and so on.

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Supplier Homepage Product APIs Top Quality Dutasteride Powder (164653-23-9)

Top Quality Dutasteride Powder (164653-23-9)

Purchase Qty.:
1-24 25+
FOB Unit Price: US $20 US $10
Purchase Qty. (kg) FOB Unit Price
1-24 US $20
25+ US $10
Get Latest Price
Port: Guangzhou, China
Production Capacity: 25kg/Year
Payment Terms: T/T, Western Union, Paypal, Money Gram

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Basic Info
  • Model NO.: LF034
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS#: 164653-23-9
  • Transport Package: 1kg/Bag/Tin; 25kg/Drum
  • Origin: China
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP, BP
  • State: Solid
  • Storage: Cool and Dry Place
  • Trademark: N/A
  • Specification: 10-100g/Box; 25kg/drum
Product Description

Dutasteride powder (164653-23-9) 

Chemical information
Molecular Weight528.53Storage3 years -20°C powder
FormulaC27H30F6N2O22 years -80°C in solvent
CAS No.164656-23-9SynonymsDutasteride
Solubility (25°C) *In vitroDMSO62 mg/mL (117.3 mM)
Ethanol6 mg/mL (11.35 mM)
Water<1 mg/mL
In vivo  
* <1 mg/ml means slightly soluble or insoluble.

* Please note that Longfine tests the solubility of all compounds in-house, and the actual 

solubility may differ slightly from published values. This is normal and is due to slight 

batch-to-batch variations.

Dutasteride Purity & Quality
Dutasteride Purity(HPLC):   99.5% Dutasteride Identity (NMR):    Consistent with structure

HPLC spectrum of Dutasteride

Top Quality Dutasteride Powder (164653-23-9)

Proton NMR Spectrum of Dutasteride

Top Quality Dutasteride Powder (164653-23-9)

Dutasteride Biological Activity

Dutasteride is a dual 5-α reductase inhibitor 

  In vitro        

Dutasteride inhibits type-1 5AR and type-2 5AR with IC50 of 6 nM and 7 nM, respectively. 

Dutasteride is 60-fold more potent than Finasteride in its initial Ki versus type 1 5AR 

and ~5-fold more rapid in inactivating the enzyme. Dutasteride inhibits (3)H-T conversion 

to (3)H-DHT and, as anticipated, inhibits T-induced secretion of PSA and proliferation 

in LNCaP cells. Dutasteride also inhibits DHT-induced PSA secretion and cell proliferation

 with IC50 of 1 μM in LNCaP cells. Dutasteride competes for binding the LNCaP cell AR 

with an IC50 of 1.5 μM. Dutasteride (10-50 μM) results in enhanced cell death, possibly 

by apoptosis, in steroid-free medium. Dutasteride reduces cell viability and cell proliferation 

in androgen-responsive (LNCaP) and androgen-unresponsive (DU145) human 

prostate cancer(PCa) cell lines. Dutasteride results in overexpressed genes included

 genes encoding for proteins involved in biosynthesis and metabolism of androgen

 (HSD17B1;HSD17B3;CYP11B2), androgen receptor and androgen receptor 

co-regulators (AR;CCND1), and signal transduction(ERBB2;V-CAM; SOS1) whereas, 

underexpressed genes (KLK3; KLK2; DHCR24) are androgen-regulated genes (ARGs) in

 androgen-responsive (LNCaP) cell. Dutasteride inhibits FASN mRNA, protein expression 

and enzymatic activity in prostate cancer cells. 

In vivo

Dutasteride (100 mg/kg/day) has prostates about half as large as those in intact male rats 

treated with vehicle alone. Dutasteride is orally bioavailable and because of its mechanism 

of action it easily overcomes the potential liability of being >99% plasma protein bou

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