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Guangzhou Longfine Biotechnology Co., Ltd.

Finasteride Powder, Finasteride Manufacturer, Prostate manufacturer / supplier in China, offering Top Quality Oral Finasteride / Proscar Steroids Powder for Hairloss Treatment / Prostate, Test Cypionate for Muscle Building Effective Anabolic Steroid 58-20-8, Testosterone Cypionate Powder CAS: 58-20-8 and so on.

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Top Quality Oral Finasteride / Proscar Steroids Powder for Hairloss Treatment / Prostate

Purchase Qty.:
(kg)
1-24 25+
FOB Unit Price: US $20 US $10
Purchase Qty. (kg) FOB Unit Price
1-24 US $20
25+ US $10
Get Latest Price
Port: Guangzhou, China
Production Capacity: 25kg/Year
Payment Terms: T/T, Western Union, Paypal, Money Gram

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Basic Info
  • Model NO.: LF035
  • Customized: Non-Customized
  • Suitable for: Adult
  • Purity: >99%
  • CAS#: 98319-26-7
  • Transport Package: 1kg/Bag/Tin; 25kg/Drum
  • Origin: China
  • Powder: Yes
  • Certification: GMP, ISO 9001, USP, BP
  • State: Solid
  • Storage: Cool and Dry Place
  • Trademark: N/A
  • Specification: 10-100g/Box; 25kg/drum
Product Description

Top quality Oral Finasteride / Proscar Steroids Powder for Hairloss Treatment / Prostate

Finasteride Chemical information
 
Molecular Weight372.54Storage3 years -20°C powder
FormulaC23H36N2O22 years -80°C in solvent
CAS No.98319-26-7SynonymsFinasteride
Solubility (25°C) *In vitroDMSO75 mg/mL (201.32 mM)
Ethanol75 mg/mL (201.32 mM)
Water<1 mg/mL
In vivo  
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Longfine tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Finasteride Purity & Quality
 Finasteride Purity(HPLC):   99.5% Finasteride Identity (NMR):    Consistent with structure

HPLC spectrum of Finasteride

Top Quality Oral Finasteride / Proscar Steroids Powder for Hairloss Treatment / Prostate

Proton NMR Spectrum of Finasteride

Top Quality Oral Finasteride / Proscar Steroids Powder for Hairloss Treatment / Prostate

Finasteride Biological Activity
 
Description

Finasteride is a potent, reversible inhibitor of the rat type 1 5 alpha-reductase with Ki of 10.2 nM, 

used in the treatment of benign prostatic hyperplasia (BPH) and male pattern baldness (MPB).

In vitro

Finasteride binds to the type 2 isozyme-NADPH complex to form a ternary complex with Ki of 1.19 nM, 

which then rearranges to a high affinity complex (E:I) with a pseudo first order rate constant of 

1.62 ms. Finasteride dose-dependently inhibits the growth rate of the LnCap cell line. Finasteride 

markedly inhibits prostate-specific antigen (PSA) secretion and expression in LNCaP cells. 

In vivo

Finasteride induces dosage-related incidences of hypospadias (penischisis) in male offspring with a 

threshold dosage level near 0.1 mg/kg/day and a 100% effect level of 100 mg/kg/day in male rats. 

Finasteride also causes decreased anogenital distance in male offspring in male rats. Finasteride and 

castration decreases prostate weight at day 21 by 65% and 93%, respectively, in rats. Finasteride has

 no significant effect on DNA content after 4 days and decreases DNA content by a maximum of 52% 

at 14 days in rats. Finasteride causes a less intense increase in staining in which 16% of epithelial cells 

stained for tissue transglutaminase on day 9 with a return to baseline by day 14 in rats.Finasteride

induced staining is less intense with peak staining at day 4 (0.7% of epithelial cells) and a return to 

control values by day 9 in rats.

 

Finasteride COA
 
     ItemsStandard

Results

Descriptionwhite or almost white crystalline powder white crystalline powder
Identification(IR,HPLC)complies with the standard  complies
SolubilityFree soluble in chloroform and in alcohol ,very slightly soluble in water.complies
Melting pointAbout 257ºC257.0~258.5ºC
Specific rotation+12.0°~+14.0°  +14.0°
Water Content by K.Fmax.0.3%   0.15%
Residue on ignitionmax.0.1%   0.03%
Heavy Metals  max.10ppm  complies
Chromatographic purity (HPLC) 
Any individual impurity max.0.5%  0.25%
Total impurities                 max.1.0%0.58%
Assay (HPLC, based on drying)98.5%~101.0%   99.0%
Residual solvents
Acetone Max.5000ppmcomplies
ChloroformMax.60ppmcomplies
THFMax.720ppmcomplies
DichloromethaneMax.600ppmcomplies
TolueneMax.890ppmcomplies
MethanolMax3000ppmcomplies
Organic volatile substancesMeet the ICH requirements complies
Storage:Preserve in tight containers, and store at controlled room temperature.
Conclusion: The product complies with the requirements of USP 36.

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Top Quality Oral Finasteride / Proscar Steroids Powder for Hairloss Treatment / Prostate


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Top Quality Oral Finasteride / Proscar Steroids Powder for Hairloss Treatment / Prostate

 

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