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Guangzhou Longfine Biotechnology Co., Ltd.

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Supplier Homepage Product APIs Factory Supply 99.7% Raw Belinostat Powder

Factory Supply 99.7% Raw Belinostat Powder

FOB Price: US $1 / mg
Min. Order: 1 mg
Min. Order FOB Price
1 mg US $1/ mg
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Port: Guangzhou, China
Production Capacity: 1ton/Year
Payment Terms: T/T, Western Union, Paypal, Money Gram

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Basic Info
  • Model NO.: PXD101
  • Customized: Customized
  • Suitable for: Adult
  • Purity: >99%
  • Documents: Coa, HPLC, Nmr, MSDS Available
  • Molecular Weight: 318.35 G/Mol
  • Transport Package: Inner PP Bag + Outer Al Foil Bag/Tin/Drum We Can C
  • Origin: Guangzhou
  • Powder: Yes
  • Certification: USP
  • State: Solid
  • Usage: Belinostat Is Used for Scientific Research
  • CAS: 414864-00-9
  • Trademark: Longfine
  • Specification: customized
Product Description

Factory supply 99.7% Belinostat  with good price

Chemical information

 Belinostat 
 

Molecular Weight318.35Storage3 years -20°C powder
FormulaC15H14N2O4S2 years -80°C in solvent
CAS No.414864-00-9SynonymsN/A
Solubility (25°C) *In vitroDMSO64 mg/mL (201.03 mM)
Water<1 mg/mL
Ethanol<1 mg/mL
In vivo2 % DMSO+30% PEG 300+ddH2O10mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Longfine tests the solubility of all compounds in-house, and the actual solubility may 
differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Purity & Quality
 
 Belinostat  Purity(HPLC): 99.8%  Belinostat   Identity (NMR):    Consistent with structure

 

HPLC spectrum of  Belinostat 

Factory Supply 99.7% Raw Belinostat Powder

 

Biological Activity
 
DescriptionBelinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors.
In vitroBelinostat inhibits the growth of tumor cells (A2780, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852) with IC50 from 0.2-0.66 μM. PD101 shows low activity in A2780/cp70 and 2780AD cells, which are cisplatin and doxorubicin-resistant derivatives of A2780 cells. Belinostat could induce apoptosis through PARP cleavage and acetylation of histones H3/H4. [1] Belinostat inhibits bladder cancer cell growth, especially in 5637 cells, which shows accumulation of G0-G1 phase, decrease in S phase and increase in G2-M phase. [2] The growth inhibitory activity of belinostat on cell lines is not strongly influenced by the multidrug-resistant phenotype, whereas the activity of docetaxel is clearly affected. Belinostat could enhance the growth inhibitory activity of docetaxel or carboplatin in OVCAR-3 and A2780 cells. Belinostat also shows enhanced tubulin acetylation in ovarian cancer cell lines. [3] A recent study shows that Belinostat activates protein kinase A in a TGF-β signaling-dependent mechanism and decreases survivin mRNA. [4]
In vivoBelinostat indicates significant tumor growth delay in A2780 and A2780/cp70 xenograft at a dose of 10mg/kg with no effects on the body weight. [1] Belinostat also induces p21WAF1, HDAC core and cell communication genes in mouse bladder tumors. [2] Belinostat monotherapy induces dose-proportional antitumor effects with TGI of 47% at a dose of 100mg/kg in A2780 xenograft. The combination of Belinostat (100 mg/kg) with carboplatin (40 mg/kg) could delay tumor growth from 18.6 days to 22.5 days. [3] Combining with bortezomib, Belinostat results in great tumor inhibition and gastrointestinal toxicity in mice with bortezomib-resistant UMSCC-11A xenograft. [5]
 
Reference

[1] Plumb JA, et al. Mol Cancer Ther, 2003, 2(8), 721-728.

[2] Buckley MT, et al. J Transl Med, 2007, 5:49.

[3] Qian X, et al. Mol Cancer Ther, 2006, 5(8), 2086-2095.

[4] Chowdhury S, et al. J Biol Chem, 2011, 286(35), 30937-30948.

[5] Duan J, et al. Mol Cancer Ther, 2007, 6(1), 37-50.

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 Belinostat  Intermediates
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1-yl)benzenesulfonate
610801-82-6
Buying Guides


Factory Supply 99.7% Raw Belinostat Powder
 

FAQ

Q1: Can i get some samples?

A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.

Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba).

Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.

Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.

Q5: How about delivery leadtime?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)

Q6:Is there a discount?
A:Different quantity has different discount.

Q7: How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.

Q8: How to contact us ?
A:You can chat with us by Trademanager,MSN&Skype Online.
You can choose your interested products and send inquiry to us.
You can dial our telephone directly, you will get our reply.
Send Email to us.

 
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Factory Supply 99.7% Raw Belinostat Powder
 
 
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