Factory Supply 99.7% Raw Belinostat Powder
|FOB Price:||US $1 / mg|
|Min. Order:||1 mg|
|Min. Order||FOB Price|
|1 mg||US $1/ mg|
|Payment Terms:||T/T, Western Union, Paypal, Money Gram|
- Model NO.: PXD101
- Customized: Customized
- Suitable for: Adult
- Purity: >99%
- Documents: Coa, HPLC, Nmr, MSDS Available
- Molecular Weight: 318.35 G/Mol
- Transport Package: Inner PP Bag + Outer Al Foil Bag/Tin/Drum We Can C
- Origin: Guangzhou
- Powder: Yes
- Certification: USP
- State: Solid
- Usage: Belinostat Is Used for Scientific Research
- CAS: 414864-00-9
- Trademark: Longfine
- Specification: customized
Factory supply 99.7% Belinostat with good price
|Molecular Weight||318.35||Storage||3 years -20°C powder|
|Formula||C15H14N2O4S||2 years -80°C in solvent|
|Solubility (25°C) *||In vitro||DMSO||64 mg/mL (201.03 mM)|
|In vivo||2 % DMSO+30% PEG 300+ddH2O||10mg/mL|
|* <1 mg/ml means slightly soluble or insoluble.|
|* Please note that Longfine tests the solubility of all compounds in-house, and the actual solubility may|
|differ slightly from published values. This is normal and is due to slight batch-to-batch variations.|
Purity & Quality
|Belinostat Purity(HPLC):||99.8%||Belinostat Identity (NMR):||Consistent with structure|
HPLC spectrum of Belinostat
|Description||Belinostat (PXD101) is a novel HDAC inhibitor with IC50 of 27 nM in a cell-free assay, with activity demonstrated in cisplatin-resistant tumors.|
|In vitro||Belinostat inhibits the growth of tumor cells (A2780, HCT116, HT29, WIL, CALU-3, MCF7, PC3 and HS852) with IC50 from 0.2-0.66 μM. PD101 shows low activity in A2780/cp70 and 2780AD cells, which are cisplatin and doxorubicin-resistant derivatives of A2780 cells. Belinostat could induce apoptosis through PARP cleavage and acetylation of histones H3/H4.  Belinostat inhibits bladder cancer cell growth, especially in 5637 cells, which shows accumulation of G0-G1 phase, decrease in S phase and increase in G2-M phase.  The growth inhibitory activity of belinostat on cell lines is not strongly influenced by the multidrug-resistant phenotype, whereas the activity of docetaxel is clearly affected. Belinostat could enhance the growth inhibitory activity of docetaxel or carboplatin in OVCAR-3 and A2780 cells. Belinostat also shows enhanced tubulin acetylation in ovarian cancer cell lines.  A recent study shows that Belinostat activates protein kinase A in a TGF-β signaling-dependent mechanism and decreases survivin mRNA. |
|In vivo||Belinostat indicates significant tumor growth delay in A2780 and A2780/cp70 xenograft at a dose of 10mg/kg with no effects on the body weight.  Belinostat also induces p21WAF1, HDAC core and cell communication genes in mouse bladder tumors.  Belinostat monotherapy induces dose-proportional antitumor effects with TGI of 47% at a dose of 100mg/kg in A2780 xenograft. The combination of Belinostat (100 mg/kg) with carboplatin (40 mg/kg) could delay tumor growth from 18.6 days to 22.5 days.  Combining with bortezomib, Belinostat results in great tumor inhibition and gastrointestinal toxicity in mice with bortezomib-resistant UMSCC-11A xenograft. |
 Plumb JA, et al. Mol Cancer Ther, 2003, 2(8), 721-728.
 Buckley MT, et al. J Transl Med, 2007, 5:49.
 Qian X, et al. Mol Cancer Ther, 2006, 5(8), 2086-2095.
 Chowdhury S, et al. J Biol Chem, 2011, 286(35), 30937-30948.
 Duan J, et al. Mol Cancer Ther, 2007, 6(1), 37-50.
Q1: Can i get some samples?
A: Yes, we can supply the free sample, but the shipping cost be paid by our customers.
Q2: How to start orders or make payments?
A: Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T, Western Union or Paypal or Escrow(Alibaba).
Q3: How to confirm the Product Quality before placing orders?
A:You can get free samples for some products,you only need to pay the shipping cost or arrange a courier to us and take the samples.
You can send us your product specifications and requests,we will manufacture the products according to your requests.
Q4:What's your MOQ?
A:Our MOQ is 1kg. But usually we accept less quantity such as 100g on the condition that sample charge is 100% paid.
Q5: How about delivery leadtime?
A:Delivery lead time: About 3-5 days after payment confirmed. (Chinese holiday not included)
Q6:Is there a discount?
A:Different quantity has different discount.
Q7: How do you treat quality complaint?
A:First of all, our quality control will reduce the quality problem to near zero. If there is a real quality problem caused by us, we will send you free goods for replacement or refund your loss.
Q8: How to contact us ?
A:You can chat with us by Trademanager,MSN&Skype Online.
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